That will not work very well. The cloud provider needs to be set on the apiserver & controller-manager and you can't run multiple copies of those in different configurations.

Now if you don't need a cloud provider, as in you are just using these as generic VMs, you will not have access to cloud storage via the kubernetes api. Otherwise it's workable but is still not a great setup. This would essentially be a cross region cluster which is not a supported use case. You are meant to use 1 cluster per region and arrange for LB somehow (yes, this is the tricky bit).